Review Article 1, Issue 8.2
Some Challenges and Potential Issues Regarding Cone Beam Computed Tomography of the Upper Airwayhttp://dx.doi.org/10.15331/jdsm.7192
Claudine Thereza-Bussolaro, DDS, OMS, MSc1,2,3,4; Camila Pacheco-Pereira, DDS, OMR, MSc, Ph.D. candidate4,5; Manuel Lagravère, DDS, BSc, MSc, DSc4 ; Carlos Flores-Mir, DDS, BSc, MSc, DSc4
1 Professor of Dentistry, UNIFASIPE, Sinop, Brazil; 2Graduate Program Coordinator, CEOF/FAIPE, Sinop, Brazil; 3Oral Maxillofacial Surgeon, Hospital Dois Pinheiros, Sinop, Brazil; 4Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; 5University of Texas Health Sciences Center at San Antonio, Texas, United States
Breathing is essential for human survival. During clinical and intraoral evaluations, dentists can identify some phenotypic characteristics that have been linked to sleep-disordered breathing (SDB). Therefore, dentists could be engaged in screening and, when indicated, refer patients with high risk for obstructive sleep apnea (OSA) to appropriate medical specialists for a full diagnosis. Participation by the dentists in future interdisciplinary management can follow. Although cone-beam computed tomography (CBCT) is an established imaging modality in dentistry, it still carries some challenges related to volume rendering management and interpretation. This article outlines the challenges of assessing available CBCT and the use of commercially available rendering tools of the upper airway. The focus of this article is on important considerations regarding the use of this advanced imaging modality for nasopharyngeal obstruction assessments and volume reconstructions. It is suggested that dentists have an essential role in SDB screening, and when CBCT is already available, it could be used as a complementary tool for volumetric airway assessment. Such involvement implies the need for a more robust understanding of current CBCT imaging limitations and potential. Finally, the role of three-dimensional printing from upper airway three-dimensional imaging for educational purposes in dentistry is discussed.
CBCT, dentistry, sleep medicine, three-dimensional printing, upper airway obstruction
Thereza-Bussolaro C, Pacheco-Pereira C, Lagravère M, Flores-Mir C. Some challenges and potential issues regarding cone beam computed tomography of the upper airway. J Dent Sleep Med. 2021;8(2)
Sleep-disordered breathing (SDB) includes a spectrum of clinical entities such as primary snoring, upper airway resistance syndrome, obstructive hypoventilation, and obstructive sleep apnea (OSA).1-3 Upper airway obstruction and nasal craniofacial anomalies are accountable traits for the occurrence of OSA.4-6 The consequences of not promptly addressing this public health issue have been extensively explored.3,7-9,10,11 Therefore, better integration and coordination between the dental and medical communities to address SDB- related issues would likely benefit patients.12
Dentists are responsible for the diagnosis, treatment, and prevention of diseases and disorders of the oral cavity and related structures.12 They may also play an essential role13 in screening and referring potential patients with high-risk factors for SDB because the evaluation of the oral cavity, airway patency, and neck circumference can be readily performed in dental practices.14 Sometimes dental evaluations followed by radiographic images can also serve as a screening source for some chronic diseases, including SDB entities.12
Flexible nasopharyngoscopy (nasal endoscopy, NE) and magnetic resonance imaging are the most common methods used to complement the clinical assessment of the upper airway region because of its dynamic process. Some studies have acknowledged that CBCT is becoming an imaging choice for dentists during upper airway assessment,15-17 even though CBCT has shortcomings, for awake patients an in upright position. As an example, the use of available CBCT to screen for adenoid hypertrophy (AH) has shown a level of agreement between CBCT and NE.15,18 Nevertheless, appropriate three-dimensional (3D) volume rendering is still a challenge in the CBCT field.15,19,20
In dentistry, the use of CBCT 3D technology and image reconstruction is more common in the fields of oral maxillofacial surgery, implantology, and orthodontics. 3D printing is an advanced cutting-edge technology that allows the rapid conversion of information from digital 3D models into 3D physical objects.21-24 The possibilities of this imaging type in other disciplines still require further development and justification. Limited related knowledge by dentists could lead to a lack of familiarity with normal and abnormal features, which can compromise the diagnostic suspicions they can provide. In other words, some exposure is good, but with a clear understanding of the need for further training the more this type of technology is used.
The objective of this article is to address the challenges regarding CBCT’s volume rendering and the potential of the 3D technology and printing technology in the dental field as related to SDB.
CBCT’S VOLUME RENDERING CHALLENGES
The use of CBCT images for upper airway analysis through volume rendering has been used for more than a decade.25-27 It should be emphasized that using CBCT images exclusively for diagnosis of the airway is not the standard protocol and should not be encouraged because of the increased ionization radiation and the relative limitations of static imaging of a dynamic scenario. However, CBCT has been explored and suggested as an adjunctive upper airway evaluation. Nevertheless, the management of density values, also known as gray thresholding, is still a challenge in the CBCT field,15 and the need for adjustment of the threshold levels has been explored to obtain less variation during the imaging asesesment.15,19,20
Density values derive from Hounsfield unit (HU) selection, which is still a significant limitation for the imaging field of upper airway CBCT. For instance, some software has a sensitivity tool, named “HU”, to identify the density value in the scan. Still, its value does not correspond to the specific HU value of 0 for water and -1000 for air expressly set for medical CT machines.28 In addition, the shortcomings of the CBCT acquisition, such as having the patient awake and in an upright position, should be considered.
It has been reported that the thresholding preestablished during an automatic segmentation, for the depiction of the open airway, is the leading cause of its considerable variation compared to manual segmentation.29,30 The use of different thresholds even for other anatomic sites has been suggested.29 Regarding the depiction of soft tissue, only one study15 reported depicting the soft tissue (uvula and surrounding region), and the HU values maintained the same threshold of 561 for the lower bound and fluctuated between 3052 to 3250 for the upper bound.
In a recent study,15 the authors provided a literature review on airway-based studies using Dolphin software Dolphin 3D, version 11.95 premium, Dolphin imaging & management Solutions, Chatsworth, CA, USA. Six studies19,20,30-33 reported adjustment of the threshold values for the depiction of the air-filled “airway”. The authors concluded that even under similar conditions, the selection of the cutoff could have a significant bearing on the volume measurement results as well as the 3D surface. To simulate the effect of the changes, a pilot scenario was created with six threshold values (15, 25, 35, 50, 70, and 75 HU) in the same patient in the same landmark area, and surface volume distortions were observed15 (Figure 1).
A disparity in CBCT scanning parameters such as exposure time, tube current (mA), voxel size, and tube voltage has also been observed among airway studies.15,17,20,31,33-42 This variation could also affect volume rendering. Dentists, unaware of such technical information, are prone to interpretation errors. Scanning parameters variation in upper airway studies is depicted in Figure 2.
Example of the effect of the sensitivity threshold adjustment in measurement and three-dimensional reconstruction surface in Dolphin software.
Cone beam computed tomography parameters variation in upper airway studies.
3D PRINTING IN DENTISTRY
3D printing is a technology that converts a multidimensional image to a physical 3D model, enabling a more comprehensive study of human anatomic structures, especially complex anatomies. Because 3D printed models are capable of providing tactile feedback and actual depth information about anatomic and pathologic cases, it could work to help educate dentists about the normal nasopharynx anatomy and its variations and raise awareness in affected patients about the importance of looking for a specialist.22
The number of studies in dentistry exploring the use of CBCT-3D printing for upper airway is still limited. In 2012, a study reported on a prototype of the oropharynx using MIMICS software (Materialize NV, Leuven, Belgium), and from that evaluated the sensitivity threshold using Dolphin software.19 The authors of another study printed the oropharynx space and compared the accuracy between multidetector CT and CBCT.43 It was concluded that CBCT scanners offer an alternative to multidetector CT in the assessment of the oropharynx morphology. Additionally, the authors of a recent study15 developed and validated the use of 3D printed models of the nasopharyngeal area of patients with different degrees of AH, which has a prevalence ranging from 42% to 70%44 in a convenience sample and is the most common cause of upper airway obstruction in children. This study explored CBCT scan reconstructions, from available CBCTs, through Dolphin software as a mechanism to screen for AH in comparison with oral head and neck specialist direct NE assessment of the area. The prototype used, representing the adenoid and surrounding anatomy, showed 100% sensitivity and 70% specificity level, therefore correctly identifying enlarged adenoids with only 5% of false-negative cases. The authors concluded that both two-dimensional and 3D representations of the nasopharyngeal obstructed area could be a practical alternative for the assessment of the nasopharyngeal adenoidal obstruction.15 Table 1 presents a list of studies that have explored 3D printing of the upper airway.
Studies reporting 3D printed prototypes of the upper airway
3D PRINTING FOR EDUCATIONAL PURPOSES
The ability to re-create patient-specific scenarios makes 3D printing a new technology in constant evolution as a health education tool. Understanding the learning gap is the first step to create a new tool for educational purposes, which can include a variety of topics from anatomic teaching to simulation procedures.45,46
In dental education, the use of training models has been established. However, there is still a lack of educational materials to transfer practical skills on exact replicas to a real patient situation. Recently, the use of CBCT-3D printing for these detailed simulations has been successfully explored.47-50 In 2010, haptic patient models were developed to teach the relationship between the third molar and the inferior mandibular nerve.47 In 2018, studies were done in the oral maxillofacial field.48,49 One study48 simulated impacted third molar and sinus lift surgeries prototypes, and another49 explored 3D printing on hands-on training courses on dental traumatology for undergraduate students in their final year. Finally, in a 2019 study with students of endodontic dentistry, root canal treatment was performed on printed molars.50 It is believed that 3D printing from CBCT is a promising method for training residents or dental students.
Dentists’ learning gaps in screening for nasopharyngeal obstruction in CBCT could be addressed with the exploration of 3D depiction tools15 not only as a screening tool for nasopharyngeal obstruction but as an alternative for its study and education. This is because these tools are capable of providing tactile feedback and precise depth information about anatomic and pathologic cases.
It is important to stress that CBCT is not the reference standard of care for OSA, and the current diagnosis must be made by a physician based on clinical examination and polysomnography. Furthermore, the dentist’s role in these cases is to refer patients for proper assessment. Other imaging modalities reflecting the dynamics of the airway, such as dynamic upper airway CT and functional magnetic resonance imaging, could better represent the narrowing of the airway space.
The assessment of upper airway obstruction in patients at risk for SDB is essential to support adequate interdisciplinary management. Timely intervention may likely prevent any further significant health consequences. CBCT, when already available, could help streamline the referral process to a specialist in medical SDB. For this reason, awareness regarding sensitivity tools and imaging limitations in CBCT should be raised among dentists. Finally, it can be debated that there is potential in the use of 3D depiction tools in dentistry as teaching tools that should be further explored.
3D- Three dimensional
AH – Adenoid hypertrophy
CBCT – Cone-beam computed tomography
HU – Hounsfield unit scale
NE – Nasal endoscopy
OSA – Obstructive sleep apnea
SDB – Sleep-disordered breathing
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SUBMISSION & CORRESPONDENCE INFORMATION
Submitted in final revised form November 7, 2019
Accepted for publication October 25, 2020
Address correspondence to: Claudine Thereza-Bussolaro, DDS, OMS, MSc, Av dos Tarumas, 995, sala 12, cep 78556-404, Sinop-MT, Brasil. Phone number: +55(66)99205-0080; E-mail address: firstname.lastname@example.org